منابع مشابه
The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes.
Enzymes capable of inactivating tetracycline are paradoxically rare compared with enzymes that inactivate other natural-product antibiotics. We describe a family of flavoenzymes, previously unrecognizable as resistance genes, which are capable of degrading tetracycline antibiotics. From soil functional metagenomic selections, we discovered nine genes that confer high-level tetracycline resistan...
متن کاملAzithromycin, Antibiotics, Tetracycline, Microalgae, Environment.
This article has no abstract.
متن کاملFunctions of tetracycline efflux proteins that do not involve tetracycline.
Tet(L) and Tet(K) are specific antibiotic-resistance determinants. They catalyze efflux of a tetracycline(Tc)-divalent metal complex in exchange for protons, as do other Tet efflux proteins. These Tet proteins also catalyze Na+ and K+ exchange for protons. Each of the "cytoplasmic substrates", Na+, K+ and the Tc-metal ion complex, can also be exchanged for K+, a catalytic mode that accounts for...
متن کاملSulindac hepatotoxicity.
Two patients who developed painless jaundice while taking sulindac are described. Rechallenge in one case confirmed the association of hepatic damage with sulindac administration. Laboratory data and liver biopsy findings suggested a hepatitis with cholestatic features.
متن کاملTetracycline in trachoma.
IN earlier reports (Agarwal and Gupta, 1954; Agarwal and Saxena, 1954), the sulphonamides and various antibiotics, including oxytetracycline (terramycin) and chlortetracycline (aureomycin), have been evaluated in the treatment of trachoma. A new antibiotic, tetracycline (Achromycin, Lederle), has recently been made available. In its pharmacological action and toxicity it resembles the two menti...
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ژورنال
عنوان ژورنال: BMJ
سال: 1965
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.5440.995