Tetracycline Hepatotoxicity

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The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes.

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Tet(L) and Tet(K) are specific antibiotic-resistance determinants. They catalyze efflux of a tetracycline(Tc)-divalent metal complex in exchange for protons, as do other Tet efflux proteins. These Tet proteins also catalyze Na+ and K+ exchange for protons. Each of the "cytoplasmic substrates", Na+, K+ and the Tc-metal ion complex, can also be exchanged for K+, a catalytic mode that accounts for...

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ژورنال

عنوان ژورنال: BMJ

سال: 1965

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.1.5440.995